Clinical Studies 2017-05-08T15:57:11+00:00

More than 170 references and scientific articles, undergraduate and PhD theses reinforce the effectiveness of INDIBA® ACTIV.

Stimulates stem cell proliferation¹

The Proionic System increases human mesenchymal stem cell proliferation by more than 25% compared to the control, without affecting stem cell pluripotentiality.

The graph shows the influence of INDIBA® Activ Therapy on stem cell proliferation in comparison to the control of non-exposed cells normalized as 100.

Improves the rate and volume of blood flow2

Color Doppler image showing blood flow rate

Color Doppler image showing blood flow rate

Power Doppler image showing blood volume

Power Doppler image showing blood volume

Positive changes in tissue blood flow at a depth of at least two centimeters under the skin in response to cutaneous application of INDIBA® have been shown in a recent study carried out in healthy volunteers in the United Kingdom as part of a PhD thesis project.

The thermal effects persist once active treatment has ended3

The thermal effects are essential for understanding the mechanism of action of INDIBA® and they last long after the treatment has ended. The thermal increase achieved after treatment is significantly greater with resistive treatment than with capacitive treatment.

Highly effective in the treatment of acute sports injuries4

Response of Patients


83% of acute patients
40% of chronic patients

Do NOT Improve

15% of acute patients
30% of chronic patients


0% of acute patients
30% of chronic patients

Its anti-inflammatory and analgesic efficacy is of great interest for treating acute sport injuries.


1 Session


1 – 5 Sessions


>5 Sessions

Percentage of improvement according to number of sessions applied.

Evolution of pain and oedema after post-operative treatment for femur fracture5

Reduction in pain on the fourth (p = 0.0045) and seventh days (p = 0.033) with INDIBA® versus control.

Evolution of oedema: Increase in muscle perimeter in both groups up to the fourth day (1 cm INDIBA® vs 1.80 cm control) p=0.009. There was subsequently a statistically significant decrease in this value in both groups, although they reached a similar value by the thirtieth day. This reduction in volume occurred sooner in the INDIBA® group.

Pain relief6

1. Hernández Bule ML, Martínez Botas J, Trillo MA et al. Antiadipogenic effects of subthermal electric stimulation at 448 kHz on differentiating human mesenchymal stem cells. Mol Med Rep 2016; DOI: 10.3892/mmr.2016.5032.

2. Kumaran B, Watson T. Capacitive Resistive Monopolar Radiofrequency (CRMRF) therapy at448 kHz: The effects on deep blood flow and elasticity of tissues. Physiotherapy UK 2015 Conference, 16–17 October 2015, Liverpool, United Kingdom.

3. Kumaran B, Watson T. Thermal build-up, decay and retention responses to local therapeuticapplication of 448 kHz capacitive resistive monopolar radiofrequency: A prospective randomised crossover study in healthy adults. Int J Hyperthermia 2015; DOI: 10.3109/02656736.2015.1092172

4. Monopolar capacitive/resistive radio-frequency 448 kHz (INDIBA®activ Therapy), working as a Rehabilitation Therapy in Sports Medicine Retrospective analysis of its application in a Sports High Performance Center (CAR Sant Cugat, Barcelona) during the period 2009-2011

5. Terranova A, Vermiglio G, Arena S, Ciciò A, di Dio S, Vermiglio M. Monopolar capacitive resistive radio-frequency 448 kHz in the post surgical treatment of femoral fracture. Eur Med Phys. 2008; 44 (Suppl 1)(3):1-2

6. Ganzit GP, Stefanini L, Stesina G. [New methods in the treatment of the muscular-joint athlete’s pathology]. Medicina dello Sport; 2000 53(4): 361-367. Italian

All of these clinical studies were conducted with INDIBA® devices.